The Hepatic Detox Profile measures the levels of D-glucaric and mercapturic acids in the urine to identify exposure to xenobiotics and assess liver function.
The Hepatic Detox Profile gives useful insight into individuals’ exposure to xenobiotics, their potential for liver disease and how well the liver is able to eliminate toxins. It does this through measuring the levels of D-glucaric and mercapturic acids in the urine, as these biomarkers provide insight into the activity of phase I and phase II detoxification respectively.
Urinary D-glucaric acid is a biomarker of enzymatic detoxification in phase I. Raised levels can therefore indicate exposure to xenobiotics, as it suggests the body is working to rid itself of the toxins it is exposed to.
Mercapturic acids are the final excretory products of phase II detoxification, and low levels suggest insufficient glutathione and/or cysteine. If levels are too low and toxins cannot be excreted properly, this impaired liver function can lead to a buildup of toxins in the body.
This test requires one urine sample, taken first thing in the morning.